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You may also find that your body composition improves and you can see more muscle definition. Yohimbe has a lot to offer. However, many people, especially those in the bodybuilding community, are particularly intrigued by Yohimbe's fat loss-boosting benefits. The mechanism by which Yohimbe aids in fat loss is quite fascinating and researchers are still trying to learn more about it. Here's what we know so far, though:.

Yohimbe acts as an Alpha-2 receptor antagonist. What this means is that it blocks the Alpha-2 receptors, which are found in the body's fat cells. When these receptors are blocked, fat loss becomes easier. When catecholamines, which are the hormones produced by your adrenal glands when the body is in a sympathetic state, bind to the beta receptors, fat cells mobilize and are ripe for fat burning.

However, when catecholamines bind to alpha receptors, the cells will not mobilize and fat burning can't take place. Since Yohimbe binds to alpha receptors, the body's catecholamines are better able to, instead, bind to the beta receptors, which allows for more efficient fat burning. Yohimbe, especially when it's combined with other stimulating ingredients, can also increase one's heart rate. This, in turn, helps the body to burn more calories both at work and at rest. As a result, you may lose more weight and more body fat when using a supplement that contains Yohimbe.

Many people notice that when they're supplementing with Yohimbe, their appetite is suppressed. This helps them to eat less and makes it easier for them to maintain a calorie deficit which, as we all know, is crucial to burning body fat and losing weight.

Yohimbe increases energy, too, and helps you push yourself for longer periods of time during workouts without feeling fatigued. When this happens, you can burn more calories and get more done while you're training, which will result in faster fat loss. Yohimbe supplementation can also be effective when you need to shed weight quickly.

This is because it can help you to get rid of excess water weight. This, in turn, helps you to look leaner and more "stage-ready," making it a good option for bodybuilders or those who are getting ready for a photo shoot or other event. Finally, Yohimbe can help to speed up the fat loss process, but it appears to do so without causing you to lose muscle mass. When you're dieting, it can be difficult to hang onto your muscle, which can result in a less-than-ideal physique and can also slow down your metabolism.

Yohimbe definitely can be beneficial to those who are looking to lose weight and shed stubborn body fat. To experience these results, though, you need to make sure you're taking it in an optimal way. Here are some factors to consider when taking a supplement that contains Yohimbe especially if you're hoping to see fat loss as a result :. Most research indicates that most people see benefits from Yohimbe when they consume around 0.

For a pound person, for example, this would equal about 14mg. Yohimbe appears to be most effective when it's consumed while in a fasted state. It also yields the best results when it's paired with consistent exercise which is why it's included in many pre-workout supplements. Taking Yohimbe while fasted helps you to avoid elevated insulin levels, which have been shown to negate its fat-loss benefits.

Many people like to use a supplement that contains Yohimbe first thing in the morning or as part of a pre-workout ritual. If you workout in the afternoon or evening, you can still see benefits from taking a supplement that contains Yohimbe. You just need to make sure your pre-workout ritual doesn't involve food.

If you're taking a pre-workout powder that contains it, for example, consider beginning with a half a scoop. That way, you can see how it affects you without having to worry about any side effects. If you don't notice any benefits, remember, you can always add more to your pre-workout cocktail next time. The body can develop a tolerance to Yohimbe fairly quickly -- within about two weeks.

Because of this, it helps to cycle on and off supplements that contain it. This will help you to continue to see benefits without having to continue increasing your dosage. The three most common side effects related to yohimbine consumption include increased anxiety, blood pressure, and cortisol levels.

Other possible side effects may include increased heart rate, headache, dizziness, nausea, vomiting, tremors, or sleeplessness. If you're consuming yohimbine to improve your erection quality, then stack it with horny goat weed. Is it safe to take Yohimbine and Glucomannan at the same time? If so, should I space out the two supplements throughout the day or take at the same time?

I am trying to lose weight with a healthy diet, exercise, and taking these supplements. Tiger Fitness Inc. This product is not intended to diagnose, treat, cure, or prevent any disease.

View cart. It appears to be most effective when taken in a fasted state. It is also used by males to improve penile blood flow and erection quality. Yohimbine hydrochloride HCL is the most commonly used form of this compound for both cases. Yohimbine HCL is chemically synthesized to offer a source of yohimbine that is not only more cost-efficient but also of higher purity and potency compared to Yohimbe bark extract. Those choosing the natural route may prefer products with yohimbine extracted from yohimbine bark or dried yohimbine bark steeped in hot water.

A yohimbine HCL dosage of 0. Mayo Clinic, Micromedex, 1 Apr. In Iverson L. Biochemistry of Biogenic Amines. Norepinephrine and Impulsivity: Effects of Acute Yohimbine.?

Psychopharmacology British Journal of Clinical Pharmacology Consuming yohimbine before exercise or during fasting increased fat breakdown in three small clinical trials [ 9 , 10 , 11 ].

In lean and obese mice, yohimbine reduced appetite and food intake [ 12 ]. Although promising, the evidence to support the use of yohimbine in weight loss comes from a few small clinical trials and a study in mice. Larger, more robust clinical trials are needed to confirm these preliminary results. Fear extinction is a form of therapy that helps get rid of the fear of certain objects, animals, or people [ 13 ]. Several studies both in animals and humans have found that yohimbine may help fear extinction by increasing norepinephrine levels [ 14 , 15 , 16 , 17 ].

In a study of 40 patients with social anxiety disorder, yohimbine decreased social anxiety and increased mood [ 18 ]. Again, the results are promising but insufficient to claim that yohimbine improves fear and social anxiety. Further clinical research is required. Among other functions, epinephrine controls blood clotting. Excessive blood clotting can lead to stroke, heart attack, and kidney failure [ 19 ].

Several clinical trials found that yohimbine reduces blood clotting by blocking alpha-2 adrenoceptors and converting epinephrine to norepinephrine.

Because they were all small, their results cannot be considered conclusive until larger, more robust trials are conducted [ 20 , 21 , 22 ]. In a study on 50 diabetic patients, yohimbine helped with blood sugar control by increasing insulin levels [ 23 ].

Yohimbine treatment also decreased blood glucose and increased insulin in diabetic rats [ 24 ]. However, a single clinical trial and a study in rats cannot be considered conclusive evidence that yohimbine improves type 2 diabetes. More clinical trials on larger populations are needed. A study in 36 adults found that yohimbine improved long-term memory by increasing norepinephrine levels [ 25 ]. However, one study showed that yohimbine reduced working memory in rats [ 26 ].

Again, the evidence to support this potential health benefit only comes from a small clinical trial. Further clinical research is needed to confirm these preliminary findings. Xerostomia, also known as dry mouth syndrome, is caused by a decrease in the amount of saliva produced. A small study in 20 people found that yohimbine increased saliva secretion [ 27 ]. Another trial on 10 people with dry mouth caused by antidepressant drugs found that yohimbine increased salivary flow 3.

Yohimbine also increased saliva secretion in dogs [ 29 ]. Yohimbine may help with dry mouth by increasing acetylcholine. This neurotransmitter increases saliva production and is controlled by alphaadrenoceptors. People with xerostomia often suffer from a lack of acetylcholine [ 29 , 27 , 30 ].

Again, the results are promising but the evidence is based on too few studies to consider it conclusive. Further clinical research on larger populations is required to confirm them. In one study, yohimbine. However, it only reduced pain in those with low blood pressure and was ineffective in 32 healthy subjects [ 31 ]. Yohimbine reduced pain in injured rats comparable to the pain medicine morphine [ 32 ].

Additional, more robust clinical research is needed to shed some light on the effects of yohimbine on pain. In 24 university students, yohimbine improved performance on a math task.

However, the number of errors was increased [ 33 ].






















Based on weekly earnings data from the Bureau of Labor Statistics , the gap has narrowed over time. That is, women's weekly earnings were There has been some progress over the years, and in the third quarter of women's weekly earnings were Overall, women who were full-time, year-round employees made That means women are paid In Wyoming, for instance, the gender pay gap is That is, median earnings of women who in this state make In 33 states, the gender pay gap is larger than the national average.

Most states have implemented laws against gender discrimination , and the Civil Rights Act protects women at the federal level, yet disparities persist.

Around the US, salaries in large cities show an even greater range of pay discrepancy between men and women. The American Association of University Women , a nonprofit that advocates for gender equality, examined how much women earn compared to men in 25 major metro areas using US Census data from the American Community Survey.

Out of the 25 cities, the narrowest gender wage gap overall is in Los Angeles, where women make approximately That translates to a pay gap of Black and Hispanic women are most affected by the wage gap, especially when compared to non-Hispanic white men, who make up the largest demographic segment of the workforce.

We looked at the wage gap for different racial and ethnic groups using median earnings data for full-time, year-round workers from the US Census Bureau's 1-year American Community Survey. Asian women face the smallest wage gap — they earn Non-Hispanic white women earn When compared to Black men, Black women earn The larger disparity between non-Hispanic white men's and women of color's earnings could be attributed to the fact that "women of color suffer both because of their gender and their race," according to an April report released by the Senate Joint Economic Committee's Democratic Staff.

It is important to note that many of these factors can be directly and indirectly influenced by discrimination based on gender and race or ethnicity.

For example, societal and structural sexism often influences the jobs that women work in, and those same forces mean that women most often take on the majority of the caregiving, housework, and other unpaid responsibilities that men do not. So while experts have attributed the estimated 38 percent 16 of the wage gap that is not explained by traditional measurable factors—such as hours worked and years of experience—to the effects of discrimination, it must be understood that discrimination likely affects more than just 38 percent of the wage gap.

The most frequent way of discussing the wage gap, in terms of dollars and cents, may unintentionally obscure the real impact on working women and their families. An even larger consideration is the cumulative impact of the gender wage gap on all women working full time in the United States.

The gender wage gap is not only complex and nuanced, but it is also stubborn. Without updated and comprehensive equal pay reform, the gender wage gap has only closed by 4 cents in more than a decade. At the current pace, women are not estimated to reach pay parity with men until To begin to close the gender wage gap, women need updated comprehensive equal pay legislation, such as the Paycheck Fairness Act, 23 that will strengthen existing protections and further combat discriminatory practices.

Other robust work-family policies are also essential to truly combating the multifaceted gender wage gap so that women—who disproportionately assume much of the caregiving responsibilities in their families—are not unfairly disadvantaged by taking time to address care needs.

For example, access to paid sick days and a comprehensive paid family and medical leave program are just two of the essential policies that would help minimize job loss and ensure better economic security for all workers.

Only by enacting essential policies and shifting cultural attitudes can the United States begin to dismantle the patriarchal structures that systematically disadvantage and shortchange women and their families. Inequality of treatment marks virtually all aspects of women's working lives, beginning with wages and employment opportunities and extending to access to decision-making and managerial positions.

In addition, while more women work outside the home, a greater percentage of women than ever before act as the sole breadwinners for their families, contributing to the feminization of poverty. Other trends illustrate the persistence of the obstacles faced by women in the workplace:. Women's employment is primarily concentrated in a narrow range of sectors especially services, where access to jobs is easier but wages are often lower and job security minimal.

Even within those sectors, women find themselves clustered at the lower echelons. Women make up a greater percentage of workers in "informal" and other precarious forms of employment, which tend to lie outside the purview of labour regulations and inspection, and are therefore more prone to exploitation. A very high percentage of women in developing countries work in the informal sector. These jobs do not provide the benefits of full-time work in the formal sector including steady wages, adequate occupational health and safety conditions, job security and social protection.

In the absence of policy measures to improve earning and employment opportunities for women, there is little evidence that the situation will improve soon. The main reason that women hold part-time jobs: they cannot find full-time jobs. Child care and work in the home are the other main factors. Part-time or full-time, women's jobs are often the least secure. The higher rates of unemployment seen by women and people of color only worsen the gender and racial pay gaps.

In addition, those unemployed for longer periods face larger unemployment penalties. Someone who was unemployed for more than a year experiences a 7. BLS Unemployment Rates in The uncontrolled pay gap widens among laid off workers. In fact, we found that respondents who reported being laid off at some point during the COVID crisis saw larger pay gaps compared to those who were not laid off.

In other words, unemployed men who returned to the workforce saw higher job offers than unemployed women returning to the workforce. Rather than layoffs, some organizations might have turned to pay cuts. Those with decreased pay saw larger pay gaps. The uncontrolled pay gap widens among workers with decreased pay. Women also tend to move up the career ladder at a slower pace than men. We call this phenomenon the opportunity gap. For example, a roughly equal percentage of men and women begin their careers as individual contributors, i.

In , 75 percent of men and 76 percent of women ages 20 to 29 are in individual contributor roles. However, by age 30 to 44, 36 percent of men became supervisors or managers while only 30 percent of women did. Finally, men are much more likely to be directors or executives than women by age 45 or older. A total of 7 percent of women make it into an executive level role at any time of their lives while 12 percent of men do.

The opportunity gap widens as women progress through their career. Assumptions about what kinds of work women are best suited for is often based on gender norms and can preemptively funnel women into lower-level and lower-paid positions.

The most predominant gender norm is that women are meant to have children and will eventually become mothers and homemakers whether or not they actually do or want to , which can also result in assumptions about their proficiency, productivity levels, or commitment to their careers. Women who return to the workforce after having children are also shown to incur a wage penalty. This is the motherhood penality or the childbearing penalty.

Some research suggests that having a child or having the potential to bear children is the primary or true cause for the gender wage gap. Indeed, a study commissioned by Bright Horizons and published in found that 41 percent of employed Americans perceive working moms to be less devoted to their work and a third judged them for needing a more flexible schedule. Men, conversely, do not experience a penalty in compensation after becoming parents. Some men are paid more after having children.

How does your pay compare? Race and gender still limit opportunities to advance. We also looked at the opportunity gap by race and found that most women of color are more likely to stagnate in their careers than white women. Women across all races were more represented in the individual contributor group than white men. Sixty-six percent of Black or African American women and 67 percent of Hispanic women are individual contributors compared to 62 percent of white women, suggesting that Black or African American women and Hispanic women have a harder time climbing the corporate ladder than white women.

For comparison, 59 percent of white men in our sample are individual contributors, which is up one percent from last year. The opportunity gap offers a key insight into workplace racial bias and how it plays out in corporate America.

Asian professionals, for example, lag dramatically behind other groups in attaining leadership roles despite higher earnings in general. Asian women are most likely to be individual contributors at 73 percent. Although Asian women are closer to pay equity with white men than white women overall, only two percent of Asian women make it to the executive level while four percent of white women did.

From these metrics, it stands to reason that Asian workers are often perceived as highly capable and end up earning higher pay yet face other unfair perceptions that dissuade promotions. Indeed, race is consistently shown to have a high influence in getting call backs or interviews or a job.

Racial bias can also occur in employee referrals and performance reviews, other factors that influence receiving promotions or job offers.






















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Thread starter fz6rowner Start date Jan 31, Refer to Dealer. Radiator Service Refill Capacity: 2. Do NOT mix Castrol coolant with other brands of antifreeze, coolants or corrosion inhibitors because of possible incompatibility of inhibitors. Follow manufacturer's recommendations for coolant concentration.

If it's over i would try and pump some out, a lot of people use hand soap pumps with some rubber tube to do so. Quote from: hawkeye on 14 June , pm. Thanks guys , I put just under the 3 litre mark in it in total so need to take about cc out , will try it with a syringe and tube draw bit out , took it for ride out Saturday had a look round Thunderoad bike shop to check for leaks and engine temp all ok but will try take that oil out. Callum Cager in Training Posts: 6.






















Its unclear how many people lost their lives during the three-year conflict. By the time the armistice agreement was signed in , North Korea had lost half of its pre-war population. Carrying her wounded grandchild on her back, this elderly woman wanders among the debris of their wrecked home in the aftermath of an air raid by US planes over Pyongyang, the Communist capital of North Korea, in the fall of A fateful encounter: In the cold of winter, US lieutenant William Doernbach comes across this Korean orphan girl in a deserted village and leaves her in the care of an orphanage.

She escapes the orphanage and finds her rescuer. They reunite in May Visit the new DW website Take a look at the beta version of dw. Go to the new dw. More info OK. Wrong language? Change it here DW. COM has chosen English as your language setting. COM in 30 languages. Deutsche Welle. Audiotrainer Deutschtrainer Die Bienenretter.

Read more: North Korea: From war to nuclear weapons Detonation The fundamental difference between a hydrogen bomb and atomic bomb is in the detonation process. Date The nuclear arms race that originated in the race for atomic weapons during World War II reached a culminating point on October 30, , with the detonation of the Tsar Bomba, the largest and most powerful nuclear weapon ever constructed.

The Soviet Union had made halting progress in its own nuclear weapons program during the war, and in Soviet Premier Joseph Stalin ordered an intensification of these efforts. Soviet penetration of the British and American atomic weapons programs thanks to the activities of spies such as Klaus Fuchs aided the efforts of Soviet scientists to design and construct their own weapons. The Soviets successfully tested their first atomic weapon on August 29, , after which both superpowers upped the ante by working furiously to develop the far more powerful thermonuclear weapons, or hydrogen bombs.

From there the United States and the Soviet Union carried out a further series of open-air tests of atomic weapons. Great Britain emulated these with open air atomic weapons tests in the late s France would follow with tests in Polynesia in the s and beyond. While the Americans focused on perfecting accurate delivery systems for small to medium size atomic devices, however, the Soviets concentrated on building larger and larger devices of almost unimaginable power.

The Tsar Bomba was the outcome. Sakharov also played a significant role in designing this weapon, which incorporated multiple inter-reacting stages and was 26 feet long, almost seven feet in diameter, and weighed almost 60, pounds. A Tupolev Tu strategic bomber was designated to deliver the device from 34, feet. The bomb would be attached to a parachute to slow its descent to detonation at 13, feet, giving the bomber and its escort additional time to escape at least thirty miles away before detonation.

Even so, the crewmen were told that they only had a 50 percent chance of survival they barely made it. The detonation was astronomically powerful—over 1, times more powerful, in fact, than the combined two bombs dropped on Hiroshima and Nagasaki.

The mushroom cloud was 25 miles wide at its base and almost 60 miles wide at its top. At 40 miles high, it penetrated the stratosphere. A mushroom cloud forms over Nagasaki, Japan after the dropping of the second atomic bomb.

By Melissa Chan. Hiroshima in ruins following the atomic bomb blast. Related Stories. Here Are 3 Alternatives. Already a print subscriber? Go here to link your subscription. Need help? Visit our Help Center.

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These hormones control your metabolism, heart health, and more. To make thyroid hormones, your thyroid takes up iodine in small amounts. Without iodine, thyroid hormone production can decrease. You can get enough iodine from your diet by eating dairy products, fortified foods, and salt water fish. Iodine is also available in plant foods that grow in naturally iodine-rich soil.

You also can get the mineral by seasoning your food with iodized salt. While iodine promotes overall thyroid health, too much iodine can have a negative effect on the thyroid gland. A goiter is an enlarged thyroid gland. Your thyroid may become enlarged as a result from either hypothyroidism or hyperthyroidism.

Hyperthyroidism is an overactive thyroid gland. Non-cancerous thyroid nodules cysts can also cause thyroid gland enlargement. Sometimes a goiter develops as a direct response to iodine deficiency. Your doctor may recommend a special type of iodine called radioactive iodine to treat an overactive thyroid gland. Also called radioiodine, this medication is taken by mouth.

The risk with radioactive iodine is that it can destroy too many thyroid cells. This can decrease the amount of hormone production, leading to hypothyroidism. For this reason, radioactive iodine is usually only recommended after anti-thyroid drugs have failed. Radioactive iodine is not the same thing as iodine supplements. You should never take iodine supplements for hyperthyroidism. Radioiodine may also be a possible treatment option for thyroid cancer. It works in much the same way as hyperthyroid treatment.

When you take radioactive iodine orally, the medication destroys thyroid cells, including cancerous ones. It may be used as a treatment following thyroid surgery to make sure all cancerous cells have been removed from the body.

According to the American Cancer Society , radioactive iodine treatments significantly improve the chances of survival for people with thyroid cancer. You need more iodine in pregnancy. The recommended daily intake of iodine during pregnancy is mcg. By comparison, the recommended amount in non-pregnant adults is mcg a day. The recommended daily amount of iodine while nursing is mcg.

The same neurological benefits of iodine during pregnancy may extend to healthy brain function during childhood. This also includes a reduced risk of intellectual disability.

It is likely your child gets all the iodine they need through their diet, but if you have any questions about their iodine intake, talk to their pediatrician. As with brain development, iodine during pregnancy is associated with a healthy birth weight. One study of pregnant women with goiters found that mg of iodine taken daily for six to eight weeks was helpful in correcting goiters related to iodine deficiency.

In turn, there was an overall improvement in birth weight in newborns. In fact, taking iodine unnecessarily can cause health issues. This non-cancerous condition is most common in women of reproductive age, and it can cause painful breast lumps.

Only take iodine for this condition if your doctor specifically recommends it. Otherwise, you could be at risk of side effects from iodine toxicity.

Iodine is just one method of water disinfection. Two percent liquid iodine tincture may be added to water in five-drop increments per one quart of clear water.

If the water is cloudy, add ten drops per quart. In the case of nuclear emergencies, the Centers for Disease Control and Prevention recommends the use of potassium iodide KI to protect the thyroid gland from radiation injuries. These are available in tablet and liquid formulas.

While not completely foolproof, the sooner KI is taken, the better the thyroid is thought to be protected in the event of this kind of emergency. There are serious risks associated with KI, including gastrointestinal upset, inflammation, and allergic reaction.

Your risk for complications is higher if you already have thyroid disease. Iodine can be used topically in a liquid form to help treat and prevent infections. It works by killing bacteria in and around mild cuts and scrapes. Topical iodine should not be used on newborn babies. Follow your doctor's orders or the directions on the label.

The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses. Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

Keep from freezing. All rights reserved. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. Mayo Clinic does not endorse companies or products. Advertising revenue supports our not-for-profit mission. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. This site complies with the HONcode standard for trustworthy health information: verify here.

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You can do the reverse unit conversion from litre to gallon [UK] , or enter any two units below:. The litre spelled liter in American English and German is a metric unit of volume. The litre is not an SI unit, but along with units such as hours and days is listed as one of the "units outside the SI that are accepted for use with the SI. Half gallon [UK] equals 2. To calculate a value in gallons [UK] to the corresponding value in litres, just multiply the quantity in gallons [UK] by 4. Supose you want to convert half gallon [UK] into litres.

Note: Fractions are rounded to the nearest 8th fraction. Values are rounded to 4 significant figures.

While every effort is made to ensure the accuracy of the information provided on this website, neither this website nor its authors are responsible for any errors or omissions. Please enable Javascript to use the unit converter. The answer is 4. We assume you are converting between liter and gallon [UK]. You can understand more and change your cookies preferences here. We measure economy by miles to the gallon, but we measure in litres at the fuel pump - here you can convert between the two so you can more accurately judge your car's fuel economy.

The test roads imitate city, out-of-town and motorway driving - something that the official tests don't do - which allows you to see how the mpg could affect your pocket depending on the roads you typically drive on. Find out how economical your dream car is by looking at our new and used car reviews. If your car is efficient to drive but has taken a few dings in its time, try using one of our best car scratch removers and get it back to looking its best.

We also tested to see if WD can hide car scratches as several online videos claim.






















The best dosage for this medication is the lowest one that still provides the desired control of the patient's anxiety symptoms. Recovery Drug Addiction Fatal Dose of Clonazepam While it is rare a person ingests a fatal dose of clonazepam, that doesn't mean that people who are taking this medication shouldn't exercise caution when using it.

Facts About Clonazepam Clonazepam is classified as a benzodiazepine. To fit into this family of medications, a drug must have one or more of the following properties : Anti-convulsant Anxiety reliever Hypnotic Memory-loss inducer mild Muscle relaxant Long Term Effects of Adderall Slogans Against Drug Abuse Effects of Using Crack Cocaine Since benzodiazepines are sedatives, they have a high potential for abuse.

How Clonazepam Works Clonazepam works by increasing the effects of a brain chemical known as gamma-amino-aminobutyric acid GABA , which helps create a feeling of calmness. Fatal Dose of Clonazepam and Mixing Drugs Unlike barbiturates, clonazepam and other medications in this class are less likely to cause respiratory depression in users.

Typical Dosage and Overdose Depending on the type of physical or mental disorder your doctor is treating, your dose of clonazepam will vary slightly. In general: For adults taking this medication for seizures, dosage should not exceed around 20 mg per day. For adults taking this for panic disorder, dosage tends to be around a maximum of 4 mg per day.

With elderly patients , doses typically begin slightly lower than adults due to a susceptibility to confusion, liver problems, drowsiness, and other physical related issues that can impact the effectiveness of the drug.

Minor toxicity has been noted as high as 2,mg in humans, and the lethal dose in small animals has been recorded at around 13,mg. Mixing Drugs With Clonazepam A person who takes a very high dose of clonazepam is unlikely to die as a result. People who are using clonazepam may be combining this medication with one or more of the following: Anticonvulsants Antidepressants Antihistamines Neuroleptics a type of tranquilizer Seizure medications Sleeping pills Mixing certain SSRI Selective Serotonin Reuptake Inhibitors with clonazepam can increase the medication's sedative effect.

High doses of clonazepam may result in the following symptoms: Difficulty concentrating Dizziness Double vision Drowsiness Lack of coordination Mental confusion Muscle weakness Slurred speech Elderly people may be at increased risk for these symptoms since their metabolism may be slower than that of younger adults.

Clonazepam and Alcohol In most cases where a fatal dose of clonazepam has been ingested, the true cause of death was the effect created when this drug is combined with alcohol. Signs of Overdose These reactions or symptoms are more commonly induced when this drug is mixed with other substances.

However if someone who has taken an overdose of clonazepam you may notice: Slowed reflexes Changes in breathing Confusion Loss of consciousness Coordination issues Physical weakness It is critical to call as soon as possible so the person who overdosed can be treated immediately.

Avoiding Drug Interactions To lower the risks associated with taking clonazepam and other medications in this class, people who are taking it as a prescribed medication should tell their doctor about all other drugs they are taking, including ones they are using recreationally.

Signs and Symptoms of Heroin Overdose Death. By Gabrielle Applebury. Clonazepam Drug Abuse by Snorting. By Dr. Vilma Ruddock. Clonazepam Addiction. The symptoms of an overdose on clonazepam or some other benzo can range from mild to severe, and, in some cases, be life-threatening.

The vast majority of severe or fatal clonazepam overdoses occur when it is used in combination with other CNS depressants, such as opioid medications or alcohol. If you have been prescribed clonazepam, your physician should be aware of other medications or substances you are using, including over-the-counter medications, nutritional supplements, vitamins, or alcohol.

If the physician suspects there may be an interaction, an alternative to clonazepam may be prescribed to prevent dangerous complications. The intensity of clonazepam overdose symptoms depends on several factors, including the following:.

If you suspect that you or a loved one is overdosing on clonazepam, contact emergency medical services at immediately. In the case of a clonazepam overdose, medical personnel will give the person activated charcoal to absorb some of the clonazepam while en route to the nearest hospital emergency center, thereby preventing potentially lethal symptoms. Likewise, they will administer a benzo agonist called flumazenil, which blocks and reverses the effects of clonazepam.

Lastly, to rebalance the body, the physician will likely administer intravenous fluids. If you recognize that a loved one has taken clonazepam and seems to be at immediate risk of self-harm, suicide, or violent behavior, follow these steps:.

Clonazepam has a high potential for abuse, as well as for forming a tolerance and physical dependence, and ultimately addiction. Addiction to clonazepam can be successfully treated through a multitude of therapeutic techniques, including cognitive-behavioral therapy CBT , individual and family counseling, and group support. Furthermore, research suggests that clonazepam addiction treatment is most successful if combined into a single comprehensive recovery plan with other holistic practices like art and music therapy, yoga, and meditation.

Slowed or labored breathing, as well as loss of consciousness and unresponsiveness, also indicate a serious overdose. Respiratory arrest is another sign of a severe Klonopin overdose, as the central nervous system is depressed to the point where the person stops breathing. Have questions about addiction to Klonopin? Yes, Klonopin is potentially addictive. Regular use increases the risk of dependency, and those who are addicted may experience unpleasant withdrawal symptoms if they stop taking Klonopin suddenly, such as panic attacks, seizures, irritability, tremors, trouble sleeping, and feelings of anxiety.

Once addiction occurs, quitting is incredibly difficult. For those with seizure disorders, quitting Klonopin without help from medical professionals or addiction treatment specialists can be dangerous, or even deadly. Fortunately, it is possible to get help with Klonopin addiction. Inpatient treatment may be ideal to manage withdrawal symptoms, particularly for those who do not have a strong support system at home.

Professional treatment allows those who struggle with Klonopin addiction to work through their withdrawal symptoms in a safe environment. Professional treatment centers can also help clients understand all the available options for treating underlying conditions, such as anxiety and panic disorders.

For those who need more flexible treatment, outpatient programs can also be highly effective. In this approach, those struggling with Klonopin addiction are overseen by medical professionals and treatment specialists at a daylong program, and are free to spend evenings at home. Both inpatient and outpatient programs include education, therapy, and guidance to help clients manage underlying health conditions without adding the challenge of addiction.

If you struggle with Klonopin addiction, or know someone who does, we can help. To learn more about the treatment, education and support provided at Sprout Health Group, call the number below to speak with an experienced professional about your unique experience. The Sprout Health Group editorial team is passionate about addiction treatment, recovery and mental health issues. Every article is expert-reviewed. Doctors prescribe clonazepam, or Klonopin, to millions of patients a year.

What Is Klonopin? How Klonopin Affects You Klonopin is classified as an anticonvulsant or antiseizure drug. Dangers of Klonopin Although addiction poses long-term challenges, the biggest immediate danger related to Klonopin is overdose from mixing the drug with alcohol, opioids or other substances.

Signs of Klonopin Overdose A typical dose of Klonopin is 0. Is Klonopin Addictive?






















Fall in love with the unique and memorable YHA experience. Skip to main content. Can't see the member benefit? You must be a member of Cycling UK to take advantage of this benefit. If you are a member then please login. Not a member? With an eMembership you do not receive a card as it is an electronic membership, your email is your confirmation.

With more than 4, hostels worldwide in fantastic and unique locations. Find your dream experience Hostelling International. Please accept the use of cookies before you continue. Login Register Buy Membership. Open search options. Open user options. Where do you want to go? Arrival Nights? Departure I don't have specific dates.

How was your booking experience? We'd love your feedback! What are the Membership prices and types. Here are some answers to the most popular questions about HI membership and discounts: What are the membership prices and types? Has this answered your question? Becoming a member lets you participate in these activities as well as avail discounts and membership benefits, including keeping your international travel budget in check by getting to stay at International Youth Hostels around the world.

Becoming a YHAI member means more than just availing discounted accommodation. This well-organized non-profit organization run by experienced volunteers provides you and your family everything from budget accommodation to opportunities to explore the world around you.

You could also be looking at adding to your education with different experiences, setting up a tour group, organizing a camping trip for students, or simply planning an excursion with friends. With a YHAI membership, you can be sure to get your hands on safe, clean, and reasonably priced travel accommodation. YHAI members are offered a wide variety of discounts for everything from trekking gear rentals and room tariff to food and beverages and even clothing and garments.

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Some of those unfinished lines, like the long-sought train from Denver to Boulder and Longmont, are now decades behind schedule. RTD blames those delays on unforeseen cost increases and the Great Recession. McKillop acknowledged that but said she wanted to present the board with the option. The board will have to make a decision on how to balance its long-term budget, McKillop said.

It's heart wrenching. We need it to survive and we need it to be strong. You want to know what is really going on these days, especially in Colorado. We can help you keep up. The Lookout is a free, daily email newsletter with news and happenings from all over Colorado.

Sign up here and we will see you in the morning! Host Ryan Warner will take the stage for a show resembling our Holiday Extravaganzas of yore this time with masks and vaccinations. For performers and ticket information, click here. It departs throughout the day from the Union State Bus Concourse to Civic Center Station, except it makes limited bus stops on 18th and 19th streets.

Have a car and still want to ride the RTD bus or train? All locations are served by numerous bus routes, some even have rail trains or shuttles like SkyRide and BroncosRide. Seniors 65 years and older, those with disabilities and Medicare recipients are eligible for discounts. Children 5 and under ride free with a paying adult. Kids 6 to 19 have reduced fare. Active duty U. You are required to show proof of eligibility for any discounts. Website: rtd-denver. Vacation like a VIP! Leisurely Lifestyle shares life and travel hacks, as well as cheap luxury travel.

Today, the Regional Transit District raised prices for bus and train tickets, making Denver the most expensive place to ride transit when compared to more than a dozen cities of similar size or larger.

The price hike arrives after the agency cut service in and planned more cuts to bus service in Service cuts translate to buses and trains arriving less frequently, which means riders are less likely to use transit , often hopping into a car instead. But RTD hopes that revamped discount programs will help to reverse four straight years of declining ridership.






















Oxygen and nutrients from the mother's blood are transferred across the placenta to the fetus through the umbilical cord. There it moves through a shunt called the ductus venosus. This allows some of the blood to go to the liver. But most of this highly oxygenated blood flows to a large vessel called the inferior vena cava and then into the right atrium of the heart. When oxygenated blood from the mother enters the right side of the heart, it flows into the upper chamber the right atrium.

Most of the blood flows across to the left atrium through a shunt called the foramen ovale. From the left atrium, blood moves down into the lower chamber of the heart the left ventricle. It's then pumped into the first part of the large artery coming from the heart the ascending aorta. From the aorta, the oxygen-rich blood is sent to the brain and to the heart muscle itself. While a SUA can be easily detected by the presence of only one umbilical artery lateral to the fetal bladder, the presence of supernumerary umbilical veins tends to be overlooked, as it is often difficult to check the number of umbilical veins throughout the length of the umbilical cord.

We consider that it is important to evaluate the number of umbilical cord vessels in the second trimester using ultrasound combined with color Doppler in at least three sites: the insertion sites on both the fetal abdomen and placenta, and at more than one point in the free loop of the umbilical cord. The number of umbilical cord vessels must be examined because abnormalities may suggest the presence of congenital anomalies. Single umbilical artery and its associated findings.

Obstet Gynecol. Article Google Scholar. An accessory fourth vessel of the umbilical cord. A preliminary study. Am J Obstet Gynecol. Painter D, Russell P. Four-vessel umbilical cord associated with multiple congenital anomalies. Four-vessel umbilical cord: not always a dire prognosis. J Ultrasound Med. Practice guidelines for performance of the routine mid-trimester fetal ultrasound scan.

Ultrasound Obstet Gynecol. Sadler TW. Google Scholar. The human fetal venous system: normal embryologic, anatomic, and physiologic characteristics and developmental abnormalities.

Persistent intrahepatic right umbilical vein in the fetus: a benign anatomic variant. Jeanty P. Persistent right umbilical vein: an ominous prenatal finding? Supernumerary umbilical vein resulting in a four-vessel umbilical cord. Am J Perinatol. Four-vessel umbilical cord. Neonatal outcomes in fetuses with a persistent intrahepatic right umbilical vein.

Murdoch DE. Umbilical-cord doubling. Report of a case. Prenatal diagnosis of four-vessel umbilical cord with supernumerary vein varix: a case report and literature review. J Obstet Gynaecol Res. Download references. Maria Clinic for supporting this report. You can also search for this author in PubMed Google Scholar. Both MKs and MM analyzed the case and wrote the manuscript.

TM and EO performed neonatal physical and ultrasound examinations. YT and MH performed the histological examination of the umbilical cord. All authors critically reviewed and revised the manuscript. All authors read and approved the final manuscript.

Correspondence to Fusanori Yotsumoto. Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal. Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Doctors aren't sure what causes it. The cord forms early as the baby develops.

In most cases, a single artery is found with an ultrasound. The test is done in the second trimester. It uses sound waves to make pictures of the baby fetus inside the uterus.

It helps your doctor or midwife look for problems with the heart, kidneys, or other areas. If the test shows a single artery, your doctor may do more tests while you are pregnant. For instance, you may have detailed ultrasound tests to see if there are any other problems. A scan may be done in the third trimester to see how your baby is growing. There is no treatment for a single umbilical artery. Your doctor or midwife will watch how your baby develops before and after birth.

If other problems are found, your doctor or midwife will talk to you about treatment. Follow-up care is a key part of your treatment and safety. Be sure to make and go to all appointments, and call your doctor or nurse call line if you are having problems. It's also a good idea to know your test results and keep a list of the medicines you take.






















Sulphur Dioxide - SO 2. Sulphur forms two main oxides; the gas sulphur dioxide SO 2 and the liquid sulphur trioxide SO 3.

Sulphur dioxide is a dense colourless gas, which is soluble in water, and has a suffocating and unpleasant smell of burnt matches. It has a melting point of Sulphur dioxide gas can be made directly by heating its constituent elements. Burning molten sulphur in either air or pure oxygen leads to a reaction, which produces a pale blue coloured flame. This looks quite impressive in a darkened room. Clicking on the donut icon will load a page at altmetric.

Find more information on the Altmetric Attention Score and how the score is calculated. These processes occurred and were completed within the cluster. Effects of initial structures on the reaction dynamics. Such files may be downloaded by article for research use if there is a public use license linked to the relevant article, that license may permit other uses.

A , , 18 , View Author Information. Cite this: J. A , , 18 , — Article Views Altmetric -. It is produced from the burning of fossil fuels coal and oil and the smelting of mineral ores aluminum, copper, zinc, lead, and iron that contain sulfur.

Sulfur dioxide dissolves easily in water to form sulfuric acid. Sulfuric acid is a major component of acid rain. Acid rain can damage forests and crops, change the acidity of soils, and make lakes and streams acidic and unsuitable for fish. Sulfur dioxide also contributes to the decay of building materials and paints, including monuments and statues.

Most of the sulfur dioxide released into the environment comes from electric utilities, especially those that burn coal. Some other sources of sulfur dioxide include petroleum refineries, cement manufacturing, paper pulp manufacturing, and metal smelting and processing facilities.

Locomotives, large ships, and some non-road diesel equipment currently burn high-sulfur fuel and release sulfur dioxide into the air.

In nature, volcanic eruptions can release sulfur dioxide into the air. Some dried fruits are preserved using SO2 to prevent discoloration of the fruit. SO2 is also used in bleaching materials and as a fumigant. The best answers are voted up and rise to the top. Stack Overflow for Teams — Collaborate and share knowledge with a private group.

Create a free Team What is Teams? Learn more. Are there any Sulfur Dioxide molecules in this structure? Ask Question. Asked 1 year, 8 months ago. Active 5 months ago. Viewed times.






















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Crazy credits The background of the end credits shows white silhouettes of flowers upon a yellow background. The music that plays usually is the closing theme, which is ukulele music. Alternate versions The French version digitally changes the opening title cards for each episode to the title in French. The opening sequence has also been slightly altered: the bubble words "SpongeBob SquarePants" has been replaced with a bubble version of SpongeBob.

On the board that changes colors, SpongeBob's face replaces the name SpongeBob SquarePants; the part where SpongeBob's pants bounce around the show's title has been replaced with scenery in Bikini Bottom, and the show's title is digitally altered to read "Bob l'eponge".

User reviews Review. Top review. Like it or not, this show is hard to avoid. SpongeBob is a very popular show. Its quirky humor, colorful characters, and crazy plot lines make it irresistible. It's hard to avoid this show, even if you're an adult, or a teen. This show also cheers you up very easily. You may like it, or you may not believe that you're watching something like this, but either way, it will somehow get to you.

The story lines are focused around SpongeBob, an energetic sea sponge who lives in a pineapple under the sea. Each episode focuses around him and his misadventures with other people in his town known as Bikini Bottom. His best friend is the dopey starfish Patrick, his other best friend is the land squirrel who lives in a submarine home, Sandy. Other characters in the show are SpongeBob's drowsy neighbor, Squidward, his boss at work, Mr. Krabs, the evil Plankton, and the driving school teacher Mrs.

There are a bunch of other characters in the show, but most episodes are focused around them. These days, Nickelodeon hasn't been doing so well. Most of their new shows are spin offs of old shows, and most of the new shows aren't good at all. SpongeBob is very reminiscent of older Nickelodeon shows.

Elements like quirky humor, annoying neighbors, fun plot lines, slightly dark humor in a few episodes not as much as the old Nickelodeon shows , mishaps at work, worst enemies, and mishaps due to SpongeBob's antics all make this show great.

There are times when this show can become stupid, as a matter of fact, every episode uses stupidity in a certain way. Dorg Van Dango. Tyler Perry's Young Dylan. Beyblade Burst. Transformers Cyberverse. Die Legende von Korra. Zoey Alle Serien. Die Brot-Piloten. Die Brotpiloten sind spinnefeind mit den Pizzapiloten, doch dann entdecken sie das dunkle Geheimnis der zwei.

Der Golf-Geist. Rotom auf Irrwegen! The series is set in an underwater city named Bikini Bottom , which is located on the floor of the Pacific Ocean beneath Bikini Atoll. The citizens are mostly fish of different colors who live in ship funnels and drive boatmobiles.

Special episodes of the show are usually presented from Patchy's house in Encino , California. Bubbles are seen whenever something moves quickly, and they fill the screen to transition between scenes. As a cartoon, it includes many unrealistic occurrences that could not happen underwater: fires, tears, flooding a building, inhabitants drinking liquids from glasses, bathtubs filled with what seems to be water, and fish walking instead of swimming, among other things.

SpongeBob is a yellow sea sponge. He is outgoing, optimistic, and passionate about life. He lives in a fully-furnished pineapple house. He loves his job as a fry cook at a fast-food restaurant called the Krusty Krab. His greatest goal in life is to earn his boat-driving license. He has been diligently attending Mrs. Puff's Boating School for years, but he never passes.

He is best friends with Patrick and has a pet snail named Gary. SpongeBob is voiced by Tom Kenny. Stephen Hillenburg originally called the character "SpongeBoy," but renamed him after finding out that the name was already used by a mop company.

He originally drew SpongeBob in the shape of a natural sea sponge, but later decided that a "squeaky clean square" would fit SpongeBob's nerdy personality. Patrick is a pink starfish. He lives under a rock and wears floral swim trunks. He is SpongeBob's best friend and spends his time without SpongeBob waiting for him to come back. Patrick is rather unintelligent and can make poor decisions that get both him and SpongeBob in trouble.

Patrick's attitude is usually relaxed and easygoing, but when someone is mean to him or SpongeBob, he can get angry. Patrick is voiced by Bill Fagerbakke. Stephen Hillenburg created Patrick as a "surfer dude" character who could hang out with SpongeBob during his time off from school and work.

Hillenburg wanted to convey the behavior of starfish— slow-looking but capable of violent movement- in Patrick's demeanor. Squidward is a turquoise octopus. Squidward loves to paint self-portraits and play his clarinet.

He is usually grumpy because nobody recognizes his artistic talents. He often gets annoyed with SpongeBob's optimism, but truly appreciates SpongeBob's friendship at times. Squidward is voiced by Rodger Bumpass. Stephen Hillenburg designed Squidward as an octopus because their bulbous heads give the look of an inflated sense of self-importance.

Squidward is usually drawn with six limbs because giving him a full set of eight was too difficult to animate. Krabs is a red crab. He owns the Krusty Krab and is Pearl's single father. He lives with his daughter Pearl in a hollow anchor. He is obsessed with money and will do almost anything to make a profit, even if it means overworking his employees SpongeBob and Squidward.

The only people who have more control over him than money are Pearl and his girlfriend, Mrs. Krabs is voiced by Clancy Brown , best known for his extensive live-action filmography. Stephen Hillenburg disliked having a "big-name" actor on the show but felt that Brown's voice fit the character perfectly.

Brown has defended Mr. Krabs as a character, saying he is "not a bad guy, just like your local banker or businessman. He loves Pearl too! Plankton is a green copepod a type of plankton. Along with his computer wife Karen, he runs a restaurant called the Chum Bucket across the street from the Krusty Krab.

He sells food made from chum, which is bait made from fish meat. Because of this, the Chum Bucket rarely gets any customers.